For the first time in 1995, Michelson chemically synthesized a dinucleotide in laboratory. Later on in 1970, Har Govind Khorana and K.L. A garwal for the first time chemically synthesized gene coding for tyrosine tRNA are the smallest genes containing about 80 nucleotides. In 1965, Robert w. holley and coworkers worked out first molecular structure of yeast alanine tRNA. This structure lent support to Khorana in deduction of structure of the gene. A gene is responsible for encoding mRNA, and mRNA for polypeptide chain. If the structure of a polypeptide chain is known, the structure of mRAN from genetic code dictionary and in turn the structure of gene can easily be worked out. There are two approaches for artificial synthesis of the gene, by using chemicals and through mRNAs.
ARTIFICIAL SYNTHESIS OF GENE
For the first time in 1995, Michelson chemically synthesized a dinucleotide in laboratory. Later on in 1970, Har Govind Khorana and K.L. A garwal for the first time chemically synthesized gene coding for tyrosine tRNA are the smallest genes containing about 80 nucleotides. In 1965, Robert w. holley and coworkers worked out first molecular structure of yeast alanine tRNA. This structure lent support to Khorana in deduction of structure of the gene. A gene is responsible for encoding mRNA, and mRNA for polypeptide chain. If the structure of a polypeptide chain is known, the structure of mRAN from genetic code dictionary and in turn the structure of gene can easily be worked out. There are two approaches for artificial synthesis of the gene, by using chemicals and through mRNAs.
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